pentobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may increase the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will lower the extent or outcome of tolterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will minimize the level or result of conivaptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the extent or influence of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. The efficacy of hormonal contraceptives may be decreased. Usage of a nonhormonal contraceptive is suggested.
pentobarbital will minimize the extent or impact of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will minimize the level or impact of cyclosporine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Sodium valproate and valproic acid look to minimize barbiturate metabolism; consequently, barbiturate blood amounts really should be monitored and ideal dosage changes manufactured as indicated.
pentobarbital will lessen the extent or impact of clarithromycin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
Published animal scientific studies display the administration of anesthetic and sedation medications that block NMDA receptors and/or potentiate GABA activity improve neuronal apoptosis from the acquiring Mind and end in long-time period cognitive deficits when useful for longer than three hours. The medical importance of these conclusions just isn't distinct.
Estradiol, estrone, progesterone together with other steroidal hormones: Pretreatment with or concurrent administration of phenobarbital may perhaps lessen the impact of estradiol by rising its metabolism.
pentobarbital will lower the extent or effect of atazanavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Mysterious.
pentobarbital will reduce the extent or effect of trazodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Inside the administration of this individual, it had been made a decision never get more info to initiate extracorporeal elimination tactics in The sunshine of modern opinions on the evidence suggesting an absence of clinical effectiveness of dialysis in poisoning with short-performing barbiturates, including pentobarbital [three, 4].
pentobarbital will decrease the extent or influence of cevimeline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.